Prospects for total synthesis: a vision for a totally synthetic vaccine targeting epithelial tumors.

ABSTRACT: Vaccines derived from totally synthetic carbohydrate antigens have been shown to elicit an immune response in both preclinical and clinical settings. The vaccines have been proven safe when administered in human clinical trials and are also competent at inducing antibodies that react with aberrant cells expressing the corresponding carbohydrate antigen. The most well studied vaccines have hitherto focused on single carbohydrate antigens, notwithstanding the known heterogeneity of transformed cells. Advances in synthetic organic chemistry have enabled the preparation and subsequent investigation of vaccines that contain several different tumor-associated carbohydrate antigens in a single molecule. These unimolecular constructs could, in principle, serve as superior mimics of cell surface an

SUBMITTER: Keding SJ 

PROVIDER: S-EPMC514412 | biostudies-literature | 2004 Aug

REPOSITORIES: biostudies-literature