Mitochondria-targeted dodecyltriphenylphosphonium (C₁₂TPP) combats high-fat-diet-induced obesity in mice.

ABSTRACT:

Background

A membrane-penetrating cation, dodecyltriphenylphosphonium (C₁₂TPP), facilitates the recycling of fatty acids in the artificial lipid membrane and mitochondria. C₁₂TPP can dissipate mitochondrial membrane potential and may affect total energy expenditure and body weight in animals and humans.

Methods

We investigated the metabolic effects of C₁₂TPP in isolated brown-fat mitochondria, brown adipocyte cultures and mice in vivo. Experimental approaches included the measurement of oxygen consumption, carbon dioxide production, western blotting, magnetic resonance imaging and bomb calorimetry.

Results

In mice, C₁₂TPP (50 μmol per (day•kg body weight)) in the drinking water significantly reduced body weight (12%, P<0.001

SUBMITTER: Kalinovich AV 

PROVIDER: S-EPMC5144127 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature