Partitioning heritability analysis reveals a shared genetic basis of brain anatomy and schizophrenia.

ABSTRACT: Schizophrenia is a devastating neurodevelopmental disorder with a complex genetic etiology. Widespread cortical gray matter loss has been observed in patients and prodromal samples. However, it remains unresolved whether schizophrenia-associated cortical structure variations arise due to disease etiology or secondary to the illness. Here we address this question using a partitioning-based heritability analysis of genome-wide single-nucleotide polymorphism (SNP) and neuroimaging data from 1750 healthy individuals. We find that schizophrenia-associated genetic variants explain a significantly enriched proportion of trait heritability in eight brain phenotypes (false discovery rate=10%). In particular, intracranial volume and left superior frontal gyrus thickness exhibit significant and robus

SUBMITTER: Lee PH 

PROVIDER: S-EPMC5144575 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature