Effects of Surgery and Proton Therapy on Cerebral White Matter of Craniopharyngioma Patients.

ABSTRACT:

Purpose

The purpose of this study was to determine radiation dose effect on the structural integrity of cerebral white matter in craniopharyngioma patients receiving surgery and proton therapy.

Methods and materials

Fifty-one patients (2.1-19.3 years of age) with craniopharyngioma underwent surgery and proton therapy in a prospective therapeutic trial. Anatomical magnetic resonance images acquired after surgery but before proton therapy were inspected to identify white matter structures intersected by surgical corridors and catheter tracks. Longitudinal diffusion tensor imaging (DTI) was performed to measure microstructural integrity changes in cerebral white matter. Fractional anisotropy (FA) derived from DTI was statistically analyzed for 51 atlas-based white matter struct

SUBMITTER: Uh J 

PROVIDER: S-EPMC5144582 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature