Impaired Recognition of Mycobacterium tuberculosis by Alveolar Macrophages From Diabetic Mice.

ABSTRACT:

Background

 Diabetes mellitus is associated with increased tuberculosis risk and severity. We previously reported that tuberculosis susceptibility in diabetic mice results from a delay in innate immune response to inhaled Mycobacterium tuberculosis, leading to delayed adaptive immune priming and, consequently, a higher plateau lung bacterial burden and greater immune pathology.

Methods

 We tested the capacity of alveolar macrophages from diabetic mice to phagocytose M. tuberculosis ex vivo and promote T-cell activation in vivo.

Results

 Alveolar macrophages from diabetic mice had reduced expression of CD14 and macrophage receptor with collagenous structure (MARCO), which recognize the bacterial cell wall component trehalose 6,6'-dimycolate (TDM). Diabetic alveolar mac

SUBMITTER: Martinez N 

PROVIDER: S-EPMC5144731 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature