Cingulate cortex functional connectivity predicts future relapse in alcohol dependent individuals.

ABSTRACT: Alcohol dependence is a chronic relapsing illness. Alcohol and stress cues have consistently been shown to increase craving and relapse risk in recovering alcohol dependent (AUD) patients. However, differences in functional connectivity in response to these cues have not been studied using data-driven approaches. Here, voxel-wise connectivity is used in a whole-brain investigation of functional connectivity differences associated with alcohol and stress cues and to examine whether these differences are related to subsequent relapse. In Study 1, 45, 4- to 8-week abstinent, recovering AUD patients underwent functional magnetic resonance imaging during individualized imagery of alcohol, stress, and neutral cues. Relapse measures were collected prospectively for 90 days post-discharge from inp

SUBMITTER: Zakiniaeiz Y 

PROVIDER: S-EPMC5144743 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature