Regional correlations between [¹¹C]PIB PET and post-mortem burden of amyloid-beta pathology in a diverse neuropathological cohort.

ABSTRACT: Imaging-pathological correlation studies show that in vivo amyloid-β (Aβ) positron emission tomography (PET) strongly predicts the presence of significant Aβ pathology at autopsy. We sought to determine whether regional PiB-PET uptake would improve sensitivity for amyloid detection in comparison with global measures (experiment 1), and to estimate the relative contributions of different Aβ aggregates to in vivo PET signal (experiment 2). In experiment 1, 54 subjects with [¹¹C] PiB-PET during life and postmortem neuropathologic examination (85.2% with dementia, interval from PET to autopsy 3.1 ± 1.9 years) were included. We assessed Thal amyloid phase (N = 36) and CERAD score (N = 54) versus both global and regional PiB SUVRs. In experiment 2 (N = 42), PiB SUVR and

SUBMITTER: Seo SW 

PROVIDER: S-EPMC5144753 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature