Listeria monocytogenes regulates flagellar motility gene expression through MogR, a transcriptional repressor required for virulence.

ABSTRACT: Previous studies have shown that Listeria monocytogenes flagellar motility genes, including flaA, encoding flagellin, are transcriptionally down-regulated at 37 degrees C. For some L. monocytogenes strains, temperature-dependent motility gene expression is less stringent. By using flaA-lacZ transcriptional fusions, we identified regions upstream of the -35/-10 promoter elements that are necessary for temperature-dependent expression of flaA in L. monocytogenes strain EGDe. Whereas the sequence of the flaA promoter region was identical in L. monocytogenes strain 10403S, transcriptional activity was only partially down-regulated at 37 degrees C in 10403S. This finding suggested that a transacting regulatory protein with differential expression or activity in EGDe might be involved in tempera

SUBMITTER: Grundling A 

PROVIDER: S-EPMC514476 | biostudies-literature | 2004 Aug

REPOSITORIES: biostudies-literature