Diversity Outbred Mice at 21: Maintaining Allelic Variation in the Face of Selection.

ABSTRACT: Multi-parent populations (MPPs) capture and maintain the genetic diversity from multiple inbred founder strains to provide a resource for high-resolution genetic mapping through the accumulation of recombination events over many generations. Breeding designs that maintain a large effective population size with randomized assignment of breeders at each generation can minimize the impact of selection, inbreeding, and genetic drift on allele frequencies. Small deviations from expected allele frequencies will have little effect on the power and precision of genetic analysis, but a major distortion could result in reduced power and loss of important functional alleles. We detected strong transmission ratio distortion in the Diversity Outbred (DO) mouse population on chromosome 2, caused by meio

SUBMITTER: Chesler EJ 

PROVIDER: S-EPMC5144960 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature