Regulation of Secondary Metabolism by the Velvet Complex Is Temperature-Responsive in Aspergillus.

ABSTRACT: Sensing and responding to environmental cues is critical to the lifestyle of filamentous fungi. How environmental variation influences fungi to produce a wide diversity of ecologically important secondary metabolites (SMs) is not well understood. To address this question, we first examined changes in global gene expression of the opportunistic human pathogen, Aspergillus fumigatus, after exposure to different temperature conditions. We found that 11 of the 37 SM gene clusters in A. fumigatus were expressed at higher levels at 30° than at 37°. We next investigated the role of the light-responsive Velvet complex in environment-dependent gene expression by examining temperature-dependent transcription profiles in the absence of two key members of the Velvet protein complex, VeA and LaeA We fo

SUBMITTER: Lind AL 

PROVIDER: S-EPMC5144971 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature