Farnesoid X Receptor and Its Ligands Inhibit the Function of Platelets.

ABSTRACT:

Objective

Although initially seemingly paradoxical because of the lack of nucleus, platelets possess many transcription factors that regulate their function through DNA-independent mechanisms. These include the farnesoid X receptor (FXR), a member of the superfamily of ligand-activated transcription factors, that has been identified as a bile acid receptor. In this study, we show that FXR is present in human platelets and FXR ligands, GW4064 and 6α-ethyl-chenodeoxycholic acid, modulate platelet activation nongenomically.

Approach and results

FXR ligands inhibited the activation of platelets in response to stimulation of collagen or thrombin receptors, resulting in diminished intracellular calcium mobilization, secretion, fibrinogen binding, and aggregation. Exposure to FXR l

SUBMITTER: Moraes LA 

PROVIDER: S-EPMC5144997 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature