Deep Insight into the Phosphatomes of Parasitic Protozoa and a Web Resource ProtozPhosDB.

ABSTRACT: Phosphorylation dynamically regulates the function of proteins by maintaining a balance between protein kinase and phosphatase activity. A comprehensive understanding of the role phosphatases in cellular signaling is lacking in case of protozoans of medical and veterinary importance worldwide. The drugs used to treat protozoal diseases have many undesired effects and the development of resistance, highlights the need for new effective and safer antiprotozoal agents. In the present study we have analyzed phosphatomes of 15 protozoans of medical significance. We identified ~2000 phosphatases, out of which 21% are uncharacterized proteins. A significant positive correlation between phosphatome and proteome size was observed except for E. histolytica, having highest density of phosphatases irr

SUBMITTER: Anwar T 

PROVIDER: S-EPMC5145157 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature