Natural and Undetermined Sudden Death: Value of Post-Mortem Genetic Investigation.

ABSTRACT:

Background

Sudden unexplained death may be the first manifestation of an unknown inherited cardiac disease. Current genetic technologies may enable the unraveling of an etiology and the identification of relatives at risk. The aim of our study was to define the etiology of natural deaths, younger than 50 years of age, and to investigate whether genetic defects associated with cardiac diseases could provide a potential etiology for the unexplained cases.

Methods and findings

Our cohort included a total of 789 consecutive cases (77.19% males) <50 years old (average 38.6±12.2 years old) who died suddenly from non-violent causes. A comprehensive autopsy was performed according to current forensic guidelines. During autopsy a cause of death was identified in most cases (81.1%), m

SUBMITTER: Sanchez O 

PROVIDER: S-EPMC5145162 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature