Endothelin B Receptors on Primary Chicken Muller Cells and the Human MIO-M1 Muller Cell Line Activate ERK Signaling via Transactivation of Epidermal Growth Factor Receptors.

ABSTRACT: Injury to the eye or retina triggers Müller cells, the major glia cell of the retina, to dedifferentiate and proliferate. In some species they attain retinal progenitor properties and have the capacity to generate new neurons. The epidermal growth factor receptor (EGFR) system and extracellular signal-regulated kinase (ERK) signaling are key regulators of these processes in Müller cells. The extracellular signals that modulate and control these processes are not fully understood. In this work we studied whether endothelin receptor signaling can activate EGFR and ERK signaling in Müller cells. Endothelin expression is robustly upregulated at retinal injury and endothelin receptors have been shown to transactivate EGFRs in other cell types. We analyzed the endothelin signaling system in chic

SUBMITTER: Harun-Or-Rashid M 

PROVIDER: S-EPMC5145189 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature