Caveolin-1 Deletion Prevents Hypertensive Vascular Remodeling Induced by Angiotensin II.

ABSTRACT: It has been proposed that membrane microdomains, caveolae, in vascular cells are critical for signal transduction and downstream functions induced by angiotensin II (AngII). We have tested our hypothesis that caveolin-1 (Cav1), a major structural protein of vascular caveolae, plays a critical role in the development of vascular remodeling by AngII via regulation of epidermal growth factor receptor and vascular endothelial adhesion molecule-1. Cav1^-/- and control Cav^+/+ mice were infused with AngII for 2 weeks to induce vascular remodeling and hypertension. On AngII infusion, histological assessments demonstrated medial hypertrophy and perivascular fibrosis of aorta and coronary and renal arteries in Cav1^+/+ mice compared with sham-operated Cav1^+/+

SUBMITTER: Forrester SJ 

PROVIDER: S-EPMC5145768 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature