A humanized mouse model of anaphylactic peanut allergy.

ABSTRACT:

Background

Food allergy is a growing health problem with very limited treatment options. Investigation of the immunologic pathways underlying allergic sensitization to foods in humans has been greatly constrained by the limited availability of intestinal tissue and gut-resident immune cells. Although mouse models have offered insights into pathways of food sensitization, differences between rodent and human immune physiology limit the extension of these findings to our understanding of human disease.

Objective

We sought to develop a strategy for the generation of mice with humanized adaptive immune systems, complete with tissue engraftment by human mast cells that are competent to mount specific IgE-mediated responses and drive systemic anaphylaxis on ingestion challenge.

SUBMITTER: Burton OT 

PROVIDER: S-EPMC5145786 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature