Cognitive Change during the Life Course and Leukocyte Telomere Length in Late Middle-Aged Men.

ABSTRACT: Importance: Cognitive skills are known to decline through the lifespan with large individual differences. The molecular mechanisms for this decline are incompletely understood. Although leukocyte telomere length provides an index of cellular age that predicts the incidence of age-related diseases, it is unclear whether there is an association between cognitive decline and leukocyte telomere length. Objective: To examine the association between changes in cognitive function during adult life and leukocyte telomere length after adjusting for confounding factors such as education, mental health and life style. Design, Setting, and Participants: Two groups of men with negative (n = 97) and positive (n = 93) change in cognitive performance were selected from a

SUBMITTER: Rask L 

PROVIDER: S-EPMC5145851 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature