Neural Correlates for Apathy: Frontal-Prefrontal and Parietal Cortical- Subcortical Circuits.

ABSTRACT: Apathy is an uncertain nosographical entity, which includes reduced motivation, abulia, decreased empathy, and lack of emotional involvement; it is an important and heavy-burden clinical condition which strongly impacts in everyday life events, affects the common daily living abilities, reduced the inner goal directed behavior, and gives the heaviest burden on caregivers. Is a quite common comorbidity of many neurological disease, However, there is no definite consensus on the role of apathy in clinical practice, no definite data on anatomical circuits involved in its development, and no definite instrument to detect it at bedside. As a general observation, the occurrence of apathy is connected to damage of prefrontal cortex (PFC) and basal ganglia; "emotional affective" apathy may be rela

SUBMITTER: Moretti R 

PROVIDER: S-EPMC5145860 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature