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Low Double-Negative CD3⁺CD4^-CD8^- T Cells Are Associated with Incomplete Restoration of CD4⁺ T Cells and Higher Immune Activation in HIV-1 Immunological Non-Responders.

ABSTRACT: Failure of immune reconstitution increases the risk of AIDS or non-AIDS related morbidity and mortality in HIV-1-infected patients. CD3⁺CD4^-CD8^- T cells, which are usually described as double-negative (DN) T cells, display CD4-like helper and immunoregulatory functions. Here, we have measured the percentage of DN T cells in the immune reconstituted vs. non-immune reconstituted HIV-1-infected individuals. We observed that immunological non-responders (INRs) had a low number of DN T cells after long-term antiretroviral therapy (ART), and the number of these cells positively correlated with the CD4⁺ T cell count. The ART did not result in complete suppression of immune activation recorded by the percentage of CD38⁺HLA-DR⁺CD8

SUBMITTER: Lu X

PROVIDER: S-EPMC5145861 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature

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Dataset Information

Low Double-Negative CD3⁺CD4^-CD8^- T Cells Are Associated with Incomplete Restoration of CD4⁺ T Cells and Higher Immune Activation in HIV-1 Immunological Non-Responders.

OmicsDI is part of the ELIXIR infrastructure

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Dataset Information

Low Double-Negative CD3+CD4-CD8- T Cells Are Associated with Incomplete Restoration of CD4+ T Cells and Higher Immune Activation in HIV-1 Immunological Non-Responders.

OmicsDI is part of the ELIXIR infrastructure

Tweets

Low Double-Negative CD3⁺CD4^-CD8^- T Cells Are Associated with Incomplete Restoration of CD4⁺ T Cells and Higher Immune Activation in HIV-1 Immunological Non-Responders.