Host-Microbiome Interaction and Cancer: Potential Application in Precision Medicine.

ABSTRACT: It has been experimentally shown that host-microbial interaction plays a major role in shaping the wellness or disease of the human body. Microorganisms coexisting in human tissues provide a variety of benefits that contribute to proper functional activity in the host through the modulation of fundamental processes such as signal transduction, immunity and metabolism. The unbalance of this microbial profile, or dysbiosis, has been correlated with the genesis and evolution of complex diseases such as cancer. Although this latter disease has been thoroughly studied using different high-throughput (HT) technologies, its heterogeneous nature makes its understanding and proper treatment in patients a remaining challenge in clinical settings. Notably, given the outstanding role of host-microbiom

SUBMITTER: Contreras AV 

PROVIDER: S-EPMC5145879 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature