Forced treadmill exercise can induce stress and increase neuronal damage in a mouse model of global cerebral ischemia.

ABSTRACT: Physical exercise is known to be a beneficial factor by increasing the cellular stress tolerance. In ischemic stroke, physical exercise is suggested to both limit the brain injury and facilitate behavioral recovery. In this study we investigated the effect of physical exercise on brain damage following global cerebral ischemia in mice. We aimed to study the effects of 4.5 weeks of forced treadmill running prior to ischemia on neuronal damage, neuroinflammation and its effect on general stress by measuring corticosterone in feces. We subjected C57bl/6 mice (n = 63) to either treadmill running or a sedentary program prior to induction of global ischemia. Anxious, depressive, and cognitive behaviors were analyzed. Stress levels were analyzed using a corticosterone ELISA. Inflammatory and neur

SUBMITTER: Svensson M 

PROVIDER: S-EPMC5145912 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature