Thyroid hormone suppresses expression of stathmin and associated tumor growth in hepatocellular carcinoma.

ABSTRACT: Stathmin (STMN1), a recognized oncoprotein upregulated in various solid tumors, promotes microtubule disassembly and modulates tumor growth and migration activity. However, the mechanisms underlying the genetic regulation of STMN1 have yet to be elucidated. In the current study, we report that thyroid hormone receptor (THR) expression is negatively correlated with STMN1 expression in a subset of clinical hepatocellular carcinoma (HCC) specimens. We further identified the STMN1 gene as a target of thyroid hormone (T₃) in the HepG2 hepatoma cell line. An analysis of STMN1 expression profile and mechanism of transcriptional regulation revealed that T₃ significantly suppressed STMN1 mRNA and protein expression, and further showed that THR directly targeted the STMN1 upstr

SUBMITTER: Tseng YH 

PROVIDER: S-EPMC5146664 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature