Increased Age-Dependent Risk of Death Associated With lukF-PV-Positive Staphylococcus aureus Bacteremia.

ABSTRACT:

Background

Panton-Valentine leucocidin is a Staphylococcus aureus virulence factor encoded by lukF-PV and lukS-PV that is infrequent in S aureus bacteremia (SAB), and, therefore, little is known about risk factors and outcome of lukF-PV/lukS-PV-positive SAB.

Methods

This report is a register-based nationwide observational cohort study. lukF-PV was detected by polymerase chain reaction. Factors associated with the presence of lukF-PV were assessed by logistic regression analysis. Adjusted 30-day hazard ratios of mortality associated with lukF-PV status were computed by Cox proportional hazards regression analysis.

Results

Of 9490 SAB cases, 129 were lukF-PV-positive (1.4%), representing 14 different

SUBMITTER: Knudsen TA 

PROVIDER: S-EPMC5146761 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature