Expression profiling and functional annotation of noncoding genes across 11 distinct organs in rat development.

ABSTRACT: Accumulating evidence suggests that noncoding RNAs (ncRNAs) have important regulatory functions. However, lacking of functional annotations for ncRNAs hampered us from carrying out the subsequent functional or predictive research. Here we dissected the expression profiles of 3,458 rat noncoding genes using rat bodymap RNA-sequencing data consisting of 11 solid organs over four developmental stages (juvenile, adolescent, adult and aged) from both sexes, and conducted a comprehensive analysis of differentially expressed noncoding genes (DEnGs) between various conditions. We then constructed a co-expression network between protein-coding and noncoding genes to infer biological functions of noncoding genes. Modules of interest were linked to online databases including DAVID for functional anno

SUBMITTER: Wen Z 

PROVIDER: S-EPMC5146941 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature