High-throughput compound evaluation on 3D networks of neurons and glia in a microfluidic platform.

ABSTRACT: With great advances in the field of in vitro brain modelling, the challenge is now to implement these technologies for development and evaluation of new drug candidates. Here we demonstrate a method for culturing three-dimensional networks of spontaneously active neurons and supporting glial cells in a microfluidic platform. The high-throughput nature of the platform in combination with its compatibility with all standard laboratory equipment allows for parallel evaluation of compound effects.

SUBMITTER: Wevers NR 

PROVIDER: S-EPMC5146966 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature