Association study of polymorphisms in the excitatory amino acid transporter 2 gene (SLC1A2) with schizophrenia.

ABSTRACT:

Background

The glutamatergic dysfunction hypothesis of schizophrenia suggests that genes involved in glutametergic transmission are candidates for schizophrenic susceptibility genes. We have been performing systematic association studies of schizophrenia with the glutamate receptor and transporter genes. In this study we report an association study of the excitatory amino acid transporter 2 gene, SLC1A2 with schizophrenia.

Methods

We genotyped 100 Japanese schizophrenics and 100 controls recruited from the Kyushu area for 11 single nucleotide polymorphism (SNP) markers distributed in the SLC1A2 region using the direct sequencing and pyrosequencing methods, and examined allele, genotype and haplotype association with schizophrenia. The positive finding observed in the Kyushu

SUBMITTER: Deng X 

PROVIDER: S-EPMC514708 | biostudies-literature | 2004 Aug

REPOSITORIES: biostudies-literature