Triiodothyronine supplementation and cytokines during cardiopulmonary bypass in infants and children.

ABSTRACT:

Objective

The Triiodothyronine Supplementation in Infants and Children Undergoing Cardiopulmonary Bypass (TRICC) study demonstrated a shortened time to extubation in children younger than 5 months old undergoing cardiopulmonary bypass for congenital heart surgery with triiodothyronine supplementation. Cardiopulmonary bypass precipitates a systemic inflammatory response that affects recovery, and triiodothyronine is related to cytokine mediators of inflammation. We sought to investigate the preoperative cytokine levels by age and relationship to the triiodothyronine levels and to examine the effect of the cytokine levels on the time to extubation.

Methods

We measured 6 cytokines at preoperative time 0 and 6 and 24 hours after crossclamp removal in 76 subjects.

Results

SUBMITTER: Priest JR 

PROVIDER: S-EPMC5147421 | biostudies-literature | 2012 Oct

REPOSITORIES: biostudies-literature