Ontology highlight
ABSTRACT:
SUBMITTER: Li D
PROVIDER: S-EPMC5147489 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
Biochemical and biophysical research communications 20161103 1-2
A better understanding of the mechanisms underlying obesity and its comorbidities is key to designing new therapies and treatments. PPARγ is a master regulator of adipocyte biology but the functions of its isoforms are poorly distinguished. Here we demonstrated that PPARγ1 is preferentially expressed in catabolic fat depots while PPARγ2 presents itself at a higher level in browning-resistant depots. PPARγ2, but not PPARγ1, responds to endogenous ligands to induce adipogenesis, and the isoforms r ...[more]