Ontology highlight
ABSTRACT:
SUBMITTER: Conti HR
PROVIDER: S-EPMC5147498 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Cell host & microbe 20161027 5
Signaling through the IL-17 receptor (IL-17R) is required to prevent oropharyngeal candidiasis (OPC) in mice and humans. However, the IL-17-responsive cell type(s) that mediate protection are unknown. Using radiation chimeras, we were able to rule out a requirement for IL-17RA in the hematopoietic compartment. We saw remarkable concordance of IL-17-controlled gene expression in C. albicans-infected human oral epithelial cells (OECs) and in tongue tissue from mice with OPC. To interrogate the rol ...[more]