Neural Architecture of Hunger-Dependent Multisensory Decision Making in C. elegans.

ABSTRACT: Little is known about how animals integrate multiple sensory inputs in natural environments to balance avoidance of danger with approach to things of value. Furthermore, the mechanistic link between internal physiological state and threat-reward decision making remains poorly understood. Here we confronted C. elegans worms with the decision whether to cross a hyperosmotic barrier presenting the threat of desiccation to reach a source of food odor. We identified a specific interneuron that controls this decision via top-down extrasynaptic aminergic potentiation of the primary osmosensory neurons to increase their sensitivity to the barrier. We also establish that food deprivation increases the worm's willingness to cross the dangerous barrier by suppressing this pathway. These studies revea

SUBMITTER: Ghosh DD 

PROVIDER: S-EPMC5147516 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature