Nutraceutical properties of cumin residue generated from Ayurvedic industries using cell line models.

ABSTRACT: Spent cumin (SC), generated from Ayurvedic industry, was evaluated for its nutraceutical potential in terms of antioxidant, antidiabetic and anticancer properties, and compared with that of the raw cumin (RC). SC and RC seeds were extracted with ethyl acetate (E) and methanol (M). SCM (methanol extract) were rich in p-coumaric acid, ferulic acid, ellagic acid and cinnamic acid (6.4445, 5.8286, 2.1519, 4.3085 mg/g dry extract). SCM reduced Fe²⁺ ion (89.68 µM AA/g dry weight), scavenged DPPH radical (IC₅₀-238.6 µg/mL), better α-amylase inhibition (IC₅₀-337.22 µg/mL) and glucose uptake activity in 30.7% of L6 cells. SCM inhibited viability, retarded migration area up to 41.02%, arrested cell cycle at S phase and induced apoptosis in 2.45% of HT29 colon cancer

SUBMITTER: Arun KB 

PROVIDER: S-EPMC5147708 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature