Alternative Splicing within and between Drosophila Species, Sexes, Tissues, and Developmental Stages.

ABSTRACT: Alternative pre-mRNA splicing ("AS") greatly expands proteome diversity, but little is known about the evolutionary landscape of AS in Drosophila and how it differs between embryonic and adult stages or males and females. Here we study the transcriptomes from several tissues and developmental stages in males and females from four species across the Drosophila genus. We find that 20-37% of multi-exon genes are alternatively spliced. While males generally express a larger number of genes, AS is more prevalent in females, suggesting that the sexes adopt different expression strategies for their specialized function. While the number of total genes expressed increases during early embryonic development, the proportion of expressed genes that are alternatively spliced is highest in the very ear

SUBMITTER: Gibilisco L 

PROVIDER: S-EPMC5147784 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature