Two-Photon Microscopy Analysis of Gold Nanoparticle Uptake in 3D Cell Spheroids.

ABSTRACT: Nanomaterials can be synthesized from a wide range of material systems in numerous morphologies, creating an extremely diverse portfolio. As result of this tunability, these materials are emerging as a new class of nanotherapeutics and imaging agents. One particularly interesting nanomaterial is the gold nanoparticle. Due to its inherent biocompatibility and tunable photothermal behavior, it has made a rapid transition from the lab setting to in vivo testing. In most nanotherapeutic applications, the efficacy of the agent is directly related to the target of interest. However, the optimization of the AuNP size and shape for efficacy in vitro, prior to testing in in vivo models of a disease, has been largely limited to two dimensional monolayers of cells. Two dimensional cell cultures are u

SUBMITTER: Rane TD 

PROVIDER: S-EPMC5147918 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature