Effects of Supplementation of the Synbiotic Ecologic® 825/FOS P6 on Intestinal Barrier Function in Healthy Humans: A Randomized Controlled Trial.

ABSTRACT:

Background and aims

Probiotics, prebiotics and synbiotics have been suggested as dietary strategies to improve intestinal barrier function. This study aimed to assess the effect of two weeks synbiotic supplementation on intestinal permeability under basal and stressed conditions. Secondary aims were the assessment of two weeks synbiotic supplementation on systemic immune function and gastrointestinal symptoms including defecation pattern.

Design

Twenty healthy adults completed a double-blind, controlled, randomized, parallel design study.

Intervention

Groups either received synbiotic (1.5 × 1010 CFU Ecologic® 825 + 10 g fructo-oligosaccharides (FOS P6) per day) or control supplements for two weeks.

Outcomes

Intestinal segment specific permeability was assessed

SUBMITTER: Wilms E 

PROVIDER: S-EPMC5147956 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature