Diffusion-Based Design of Multi-Layered Ophthalmic Lenses for Controlled Drug Release.

ABSTRACT: The study of ocular drug delivery systems has been one of the most covered topics in drug delivery research. One potential drug carrier solution is the use of materials that are already commercially available in ophthalmic lenses for the correction of refractive errors. In this study, we present a diffusion-based mathematical model in which the parameters can be adjusted based on experimental results obtained under controlled conditions. The model allows for the design of multi-layered therapeutic ophthalmic lenses for controlled drug delivery. We show that the proper combination of materials with adequate drug diffusion coefficients, thicknesses and interfacial transport characteristics allows for the control of the delivery of drugs from multi-layered ophthalmic lenses, such that drug bu

SUBMITTER: Pimenta AF 

PROVIDER: S-EPMC5147977 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature