Circulating Microvesicles Are Elevated Acutely following Major Burns Injury and Associated with Clinical Severity.

ABSTRACT: Microvesicles are cell-derived signaling particles emerging as important mediators and biomarkers of systemic inflammation, but their production in severe burn injury patients has not been described. In this pilot investigation, we measured circulating microvesicle levels following severe burns, with severe sepsis patients as a comparator group. We hypothesized that levels of circulating vascular cell-derived microvesicles are elevated acutely following burns injury, mirroring clinical severity due to the early onset and prevalence of systemic inflammatory response syndrome (SIRS) in these patients. Blood samples were obtained from patients with moderate to severe thermal injury burns, with severe sepsis, and from healthy volunteers. Circulating microvesicles derived from total leukocytes,

SUBMITTER: O'Dea KP 

PROVIDER: S-EPMC5148002 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature