Change in Serum Bilirubin Level as a Predictor of Incident Metabolic Syndrome.

ABSTRACT:

Aim

Serum bilirubin level was negatively associated with the prevalence of metabolic syndrome (MetS) in previous cross-sectional studies. However, bilirubin variance preceding the development of MetS has yet to be investigated. We aimed to determine the effect of change in bilirubin concentration on the risk of incident MetS in healthy Korean adults.

Methods

We conducted a retrospective longitudinal study of subjects who had undergone at least four yearly health check-ups between 2006 and 2012. Of 24,185 total individuals who received annual check-ups, 11,613 non-MetS participants with a baseline bilirubin level not exceeding 34.2 μmol/l were enrolled. We evaluated the association between percent change in bilirubin and risk of incident MetS.

Results

During 55,407 per

SUBMITTER: Lee YB 

PROVIDER: S-EPMC5148095 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature