Bottom-Up versus Top-Down Induction of Sleep by Zolpidem Acting on Histaminergic and Neocortex Neurons.

ABSTRACT: Zolpidem, a GABA_A receptor-positive modulator, is the gold-standard drug for treating insomnia. Zolpidem prolongs IPSCs to decrease sleep latency and increase sleep time, effects that depend on α2 and/or α3 subunit-containing receptors. Compared with natural NREM sleep, zolpidem also decreases the EEG power, an effect that depends on α1 subunit-containing receptors, and which may make zolpidem-induced sleep less optimal. In this paper, we investigate whether zolpidem needs to potentiate only particular GABAergic pathways to induce sleep without reducing EEG power. Mice with a knock-in F77I mutation in the GABA_A receptor γ2 subunit gene are zolpidem-insensitive. Using these mice, GABA_A receptors in the frontal motor neocortex and hypothalamic (tuberomammilla

SUBMITTER: Uygun DS 

PROVIDER: S-EPMC5148237 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature