Nur77 gene knockout alters dopamine neuron biochemical activity and dopamine turnover.

ABSTRACT:

Background

Transcription factors of the Nur family (Nurr1, Nur77, and Nor-1) are orphan nuclear receptors closely associated with dopamine neurotransmission in the central nervous system. Nur77 expression is strongly modulated by antipsychotic and ant-parkinsonian drugs in dopaminoceptive brain areas. However, the role of Nur77 in dopamine neuron activity and turnover remains elusive.

Methods

We compared various behavioral and biochemical parameters between Nur77 knockout -/- and wild-type +/+ mice in basal and haloperidol-challenged conditions.

Results

We report here that Nur77-deficient mice display enhanced spontaneous locomotor activity, greater sensitivity to a small dose of the dopamine D2 receptor agonist quinpirole acting mainly at autoreceptor sites, and high

SUBMITTER: Gilbert F 

PROVIDER: S-EPMC5148625 | biostudies-literature | 2006 Sep

REPOSITORIES: biostudies-literature