The genetic basis of the comorbidity between cannabis use and major depression.

ABSTRACT:

Background and aims

While the prevalence of major depression is elevated among cannabis users, the role of genetics in this pattern of comorbidity is not clear. This study aimed to estimate the heritability of cannabis use and major depression, quantify the genetic overlap between these two traits and localize regions of the genome that segregate in families with cannabis use and major depression.

Design

Family-based univariate and bivariate genetic analysis.

Setting

San Antonio, Texas, USA.

Participants

Genetics of Brain Structure and Function study (GOBS) participants: 1284 Mexican Americans from 75 large multi-generation families and an additional 57 genetically unrelated spouses.

Measurements

Phenotypes of life-time history of cannabis use and major

SUBMITTER: Hodgson K 

PROVIDER: S-EPMC5148647 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature