Relationship between structural and functional connectivity change across the adult lifespan: A longitudinal investigation.

ABSTRACT: Extensive efforts are devoted to understand the functional (FC) and structural connections (SC) of the brain. FC is usually measured by functional magnetic resonance imaging (fMRI), and conceptualized as degree of synchronicity in brain activity between different regions. SC is typically indexed by measures of white matter (WM) properties, for example, by diffusion weighted imaging (DWI). FC and SC are intrinsically related, in that coordination of activity across regions ultimately depends on fast and efficient transfer of information made possible by structural connections. Convergence between FC and SC has been shown for specific networks, especially the default mode network (DMN). However, it is not known to what degree FC is constrained by major WM tracts and whether FC and SC change

SUBMITTER: Fjell AM 

PROVIDER: S-EPMC5148650 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature