Individualized therapy for persistent asthma in young children.

ABSTRACT:

Background

Phenotypic presentations in young children with asthma are varied and might contribute to differential responses to asthma controller medications.

Methods

The Individualized Therapy for Asthma in Toddlers study was a multicenter, randomized, double-blind, double-dummy clinical trial in children aged 12 to 59 months (n = 300) with asthma necessitating treatment with daily controller (Step 2) therapy. Participants completed a 2- to 8-week run-in period followed by 3 crossover periods with daily inhaled corticosteroids (ICSs), daily leukotriene receptor antagonists, and as-needed ICS treatment coadministered with albuterol. The primary outcome was differential response to asthma medication based on a composite measure of asthma control. The primary analysis involved

SUBMITTER: Fitzpatrick AM 

PROVIDER: S-EPMC5148729 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature