Bidirectional Changes in Anisotropy Are Associated with Outcomes in Mild Traumatic Brain Injury.

ABSTRACT:

Background and purpose

Mild traumatic brain injury results in a heterogeneous constellation of deficits and symptoms that persist in a subset of patients. This prospective longitudinal study identifies early diffusion tensor imaging biomarkers of mild traumatic brain injury that significantly relate to outcomes at 1 year following injury.

Materials and methods

DTI was performed on 39 subjects with mild traumatic brain injury within 16 days of injury and 40 controls; 26 subjects with mild traumatic brain injury returned for follow-up at 1 year. We identified subject-specific regions of abnormally high and low fractional anisotropy and calculated mean fractional anisotropy, axial diffusivity, radial diffusivity, and mean diffusivity across all white matter voxels brain-wide an

SUBMITTER: Strauss SB 

PROVIDER: S-EPMC5148740 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature