Cardiovascular diseases-related GNB3 C825T polymorphism has a significant sex-specific effect on serum soluble E-selectin levels.

ABSTRACT:

Background

The C825T polymorphism (rs5443) of the Guanine Nucleotide-Binding protein subunit β3 (GNB3) gene has been associated with obesity, essential hypertension, atherosclerosis, coronary diseases, and cerebrovascular events, but with some sex-specific effects. Its association with inflammatory mediators such as cell adhesion molecules has not been studied, although they are heavily involved in cardiovascular diseases' (CVDs) processes. The aim of our study was then to investigate a possible sex-specific effect of the GNB3 C825T polymorphism on serum soluble cell adhesion molecules such as E, P and L-selectins (sE, sP and sL-selectins).

Results

Participants were from the STANISLAS Family Study and were free of chronic disease as CVDs or cancer. We included

SUBMITTER: Gbadoe KM 

PROVIDER: S-EPMC5148858 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature