Resting-state functional connectivity of the amygdala and longitudinal changes in depression severity in adolescent depression.

ABSTRACT:

Background

The incidence of major depressive disorder (MDD) rises during adolescence, yet the neural mechanisms of MDD during this key developmental period are unclear. Altered amygdala resting-state functional connectivity (RSFC) has been associated with both adolescent and adult MDD, as well as symptom improvement in response to treatment in adults. However, no study to date has examined whether amygdala RSFC is associated with changes in depressive symptom severity in adolescents.

Method

We examined group differences in amygdala RSFC between medication-naïve depressed adolescents (N=48) and well-matched healthy controls (N=53) cross-sectionally. We then longitudinally examined whether baseline amygdala RSFC was associated with change in depression symptoms three months la

SUBMITTER: Connolly CG 

PROVIDER: S-EPMC5149416 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature