Proteomic characterization of the internalization of Opisthorchis viverrini excretory/secretory products in human cells.

ABSTRACT: The association between liver fluke infection caused by Opisthorchis viverrini and cholangiocarcinoma (CCA - hepatic cancer of the bile duct epithelium) has been well established. Multiple mechanisms play a role in the development of CCA, but the excretory/secretory products released by O. viverrini (OvES) represent the major interface between the parasite and its host, and their uptake by biliary epithelial cells has been suggested to be responsible for proliferation of cholangiocytes, the cells that line the biliary epithelium. Despite recent progress in the study of the molecular basis of O. viverrini-host interactions, little is known about the effects that OvES induces upon internalization by host cells. In the present study we incubated non-cancerous human cholangiocytes (H69) and hu

SUBMITTER: Chaiyadet S 

PROVIDER: S-EPMC5149449 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature