IL-17A enhances IL-13 activity by enhancing IL-13-induced signal transducer and activator of transcription 6 activation.

ABSTRACT:

Background

Increased IL-17A production has been associated with more severe asthma; however, the mechanisms whereby IL-17A can contribute to IL-13-driven pathology in asthmatic patients remain unclear.

Objective

We sought to gain mechanistic insight into how IL-17A can influence IL-13-driven responses.

Methods

The effect of IL-17A on IL-13-induced airway hyperresponsiveness, gene expression, mucus hypersecretion, and airway inflammation was assessed by using in vivo models of IL-13-induced lung pathology and in vitro culture of murine fibroblast cell lines and primary fibroblasts and human epithelial cell lines or primary human epithelial cells exposed to IL-13, IL-17A, or both.

Results

Compared with mice given intratracheal IL-13 alone, those exposed to IL-13

SUBMITTER: Hall SL 

PROVIDER: S-EPMC5149451 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature