Ontology highlight
ABSTRACT:
SUBMITTER: Nitarska J
PROVIDER: S-EPMC5149529 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Cell reports 20161101 6
Histone modifications and chromatin remodeling represent universal mechanisms by which cells adapt their transcriptional response to rapidly changing environmental conditions. Extensive chromatin remodeling takes place during neuronal development, allowing the transition of pluripotent cells into differentiated neurons. Here, we report that the NuRD complex, which couples ATP-dependent chromatin remodeling with histone deacetylase activity, regulates mouse brain development. Subunit exchange of ...[more]