Down-Regulation of microRNA-132 is Associated with Poor Prognosis of Colorectal Cancer.

ABSTRACT:

Background

Given the role of microRNA in colorectal cancer (CRC) progression, we explored the association between microRNA (miRNA) expression and CRC-related prognosis.

Methods

Three types of tissue samples (primary CRC lesions without liver metastasis, primary lesions with liver metastasis, and liver metastatic tissues) were used for miRNA profiling to identify differentially expressed miRNA. Quantitative real-time PCR was used to examine miRNA expression in CRC cells and in tumor tissues.

Results

MiR-132 was significantly down-regulated in primary CRC tissues with liver metastasis and liver metastatic lesions compared to primary lesions without liver metastasis. Multivariate analysis for overall survival indicated that low miR-132 expression was an independent progn

SUBMITTER: Mokutani Y 

PROVIDER: S-EPMC5149564 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature