Very Late Antigen-1 Marks Functional Tumor-Resident CD8 T Cells and Correlates with Survival of Melanoma Patients.

ABSTRACT: A major limiting factor in the success of immunotherapy is tumor infiltration by CD8⁺ T cells, a process that remains poorly understood. In the present study, we characterized homing receptors expressed by human melanoma-specific CD8⁺ T cells. Our data reveal that P-selectin binding and expression of the retention integrin, very late antigen (VLA)-1, by vaccine-induced T cells correlate with longer patient survival. Furthermore, we demonstrate that CD8⁺VLA-1⁺ tumor-infiltrating lymphocytes (TILs) are highly enriched in melanoma metastases in diverse tissues. VLA-1-expressing TIL frequently co-express CD69 and CD103, indicating tissue-resident memory T cells (T_RM) differentiation. We employed a mouse model of melanoma to further charact

SUBMITTER: Murray T 

PROVIDER: S-EPMC5150229 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature